YMR200W
(Redirected from S000004813)
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| Systematic name | YMR200W |
| Gene name | ROT1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:664752..665522 |
| Primary SGDID | S000004813 |
Description of YMR200W: Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation[1][2][3][4][5]
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References
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- ↑ Bickle M, et al. (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45 SGD PMID 9545237
- ↑ Pasikowska M, et al. (2012) The essential endoplasmic reticulum chaperone Rot1 is required for protein N- and O-glycosylation in yeast. Glycobiology () SGD PMID 22492205
- ↑ Takeuchi M, et al. (2006) Causal links between protein folding in the ER and events along the secretory pathway. Autophagy 2(4):323-4 SGD PMID 16874095
- ↑ Takeuchi M, et al. (2006) Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding. J Biochem 139(3):597-605 SGD PMID 16567426
- ↑ Takeuchi M, et al. (2008) Saccharomyces cerevisiae Rot1 Is an Essential Molecular Chaperone in the Endoplasmic Reticulum. Mol Biol Cell 19(8):3514-25 SGD PMID 18508919
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