YLR442C
(Redirected from S000004434)
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| Systematic name | YLR442C |
| Gene name | SIR3 |
| Aliases | CMT1, MAR2, STE8 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:1022251..1019315 |
| Primary SGDID | S000004434 |
Description of YLR442C: Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p[1][2][3]
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References
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- ↑ Hecht A, et al. (1996) Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature 383(6595):92-6 SGD PMID 8779721
- ↑ Moretti P and Shore D (2001) Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast. Mol Cell Biol 21(23):8082-94 SGD PMID 11689698
- ↑ Rine J and Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22 SGD PMID 3297920
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