YLR329W
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| Systematic name | YLR329W |
| Gene name | REC102 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:786442..787333 |
| Primary SGDID | S000004321 |
Description of YLR329W: Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination[1][2][3]
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Contents
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Interactions
Physical
Physical interaction with Rec104
Immunoprecipitation and two-hybrid interactions. Both proteins are mutually interdependent for nuclear localization and association with meiotic chromosomes, and both also depend on Spo11p and Ski8p for chromatin association. [4] [5]
Protein Details
Protein Localization
Localized to nucleus and associates with meiotic chromosomes, dependent on Rec104p. Chromatin immunoprecipitation and indirect immunofluorescence reveal substantial localization to chromatin loops (as opposed to axes). Chromatin association is abruptly lost during the pachytene stage. [4] [5]
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References
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- ↑ Bhargava J, et al. (1992) The rec102 mutant of yeast is defective in meiotic recombination and chromosome synapsis. Genetics 130(1):59-69 SGD PMID 1732169
- ↑ Jiao K, et al. (2003) Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p. Mol Cell Biol 23(16):5928-38 SGD PMID 12897161
- ↑ Malone RE, et al. (1991) Isolation of mutants defective in early steps of meiotic recombination in the yeast Saccharomyces cerevisiae. Genetics 128(1):79-88 SGD PMID 2060778
- ↑ 4.0 4.1 Kee K, et al. (2004) Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J 23(8):1815-24 SGD PMID 15044957
- ↑ 5.0 5.1 submitted by Scott Keeney on 2005-12-09
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