YLR293C

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Systematic name YLR293C
Gene name GSP1
Aliases CNR1, CST17
Feature type ORF, Verified
Coordinates Chr XII:721430..720771
Primary SGDID S000004284


Description of YLR293C: Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog[1][2][3][4][5][6][7][8]




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References

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  1. Becker J, et al. (1995) RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. J Biol Chem 270(20):11860-5 SGD PMID 7744835
  2. Belhumeur P, et al. (1993) GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Mol Cell Biol 13(4):2152-61 SGD PMID 8455603
  3. Floer M and Blobel G (1996) The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. J Biol Chem 271(10):5313-6 SGD PMID 8621381
  4. Kadowaki T, et al. (1993) Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J 12(7):2929-37 SGD PMID 7687541
  5. Kunzler M and Hurt EC (1998) Cse1p functions as the nuclear export receptor for importin alpha in yeast. FEBS Lett 433(3):185-90 SGD PMID 9744791
  6. Lee A, et al. (1994) Site-directed mutagenesis of the yeast PRP20/SRM1 gene reveals distinct activity domains in the protein product. Mol Gen Genet 245(1):32-44 SGD PMID 7845357
  7. Schlenstedt G, et al. (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14(21):5367-78 SGD PMID 7489726
  8. Schlenstedt G, et al. (1997) Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J 16(20):6237-49 SGD PMID 9321403

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