YLR153C

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Systematic name YLR153C
Gene name ACS2
Aliases
Feature type ORF, Verified
Coordinates Chr XII:447575..445524
Primary SGDID S000004143


Description of YLR153C: Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions[1][2][3]




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References

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  1. Guranowski A, et al. (1994) Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase. J Bacteriol 176(10):2986-90 SGD PMID 7910605
  2. Takahashi H, et al. (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 23(2):207-17 SGD PMID 16857587
  3. van den Berg MA, et al. (1996) The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. J Biol Chem 271(46):28953-9 SGD PMID 8910545

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