YJL090C

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Systematic name YJL090C
Gene name DPB11
Aliases
Feature type ORF, Verified
Coordinates Chr X:265051..262757
Primary SGDID S000003626


Description of YJL090C: Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1[1][2][3][4][5][6][7]




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References

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  1. Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 SGD PMID 9742127
  2. Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 SGD PMID 10733584
  3. Mordes DA, et al. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4 SGD PMID 19028869
  4. Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 SGD PMID 18922789
  5. Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 SGD PMID 17167415
  6. Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 SGD PMID 10097122
  7. Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 SGD PMID 17167417

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