YGR113W

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Systematic name YGR113W
Gene name DAM1
Aliases
Feature type ORF, Verified
Coordinates Chr VII:718893..719924
Primary SGDID S000003345


Description of YGR113W: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments[1][2][3][4][5][6]




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References

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  1. Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 SGD PMID 12408861
  2. Courtwright AM and He X (2002) Dam1 is the right one: phosphoregulation of kinetochore biorientation. Dev Cell 3(5):610-1 SGD PMID 12431367
  3. Li Y, et al. (2002) The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev 16(2):183-97 SGD PMID 11799062
  4. Miranda JJ, et al. (2005) The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol 12(2):138-43 SGD PMID 15640796
  5. Westermann S, et al. (2005) Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell 17(2):277-90 SGD PMID 15664196
  6. Westermann S, et al. (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440(7083):565-9 SGD PMID 16415853

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