YDR254W

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Systematic name YDR254W
Gene name CHL4
Aliases CTF17, MCM17
Feature type ORF, Verified
Coordinates Chr IV:965113..966489
Primary SGDID S000002662


Description of YDR254W: Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15[1][2][3][4][5][6]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in sulfur limited chemostat cultures versus sulfur excess. [7] [8]





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References

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  1. Fernius J and Marston AL (2009) Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3. PLoS Genet 5(9):e1000629 SGD PMID 19730685
  2. Kouprina NYu, et al. (1988) Genetic control of chromosome stability in the yeast Saccharomyces cerevisiae. Yeast 4(4):257-69 SGD PMID 3064490
  3. Marston AL, et al. (2004) A genome-wide screen identifies genes required for centromeric cohesion. Science 303(5662):1367-70 SGD PMID 14752166
  4. Mythreye K and Bloom KS (2003) Differential kinetochore protein requirements for establishment versus propagation of centromere activity in Saccharomyces cerevisiae. J Cell Biol 160(6):833-43 SGD PMID 12642611
  5. Pot I, et al. (2003) Chl4p and iml3p are two new members of the budding yeast outer kinetochore. Mol Biol Cell 14(2):460-76 SGD PMID 12589047
  6. Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 SGD PMID 22561346
  7. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  8. submitted by Viktor Boer on 2003-07-25

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