YDR232W

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Systematic name YDR232W
Gene name HEM1
Aliases CYD1, OLE3
Feature type ORF, Verified
Coordinates Chr IV:927452..929098
Primary SGDID S000002640


Description of YDR232W: 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p[1][2][3][4][5][6]




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References

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  1. Gollub EG, et al. (1977) Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene. J Biol Chem 252(9):2846-54 SGD PMID 323256
  2. Haldi M and Guarente L (1989) N-terminal deletions of a mitochondrial signal sequence in yeast. Targeting information of delta-aminolevulinate synthase is encoded in non-overlapping regions. J Biol Chem 264(29):17107-12 SGD PMID 2507539
  3. Keng T and Guarente L (1987) Constitutive expression of the yeast HEM1 gene is actually a composite of activation and repression. Proc Natl Acad Sci U S A 84(24):9113-7 SGD PMID 3321068
  4. Keng T, et al. (1986) The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix. Mol Cell Biol 6(2):355-64 SGD PMID 3023841
  5. Urban-Grimal D and Labbe-Bois R (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet 183(1):85-92 SGD PMID 7035824
  6. Urban-Grimal D, et al. (1986) The nucleotide sequence of the HEM1 gene and evidence for a precursor form of the mitochondrial 5-aminolevulinate synthase in Saccharomyces cerevisiae. Eur J Biochem 156(3):511-9 SGD PMID 3516694

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