YDR001C

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Systematic name YDR001C
Gene name NTH1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:452475..450220
Primary SGDID S000002408


Description of YDR001C: Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [5]





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References

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  1. Kopp M, et al. (1993) Molecular analysis of the neutral trehalase gene from Saccharomyces cerevisiae. J Biol Chem 268(7):4766-74 SGD PMID 8444853
  2. Nwaka S, et al. (1995) Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae. J Biol Chem 270(17):10193-8 SGD PMID 7730323
  3. 3.0 3.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  4. Zahringer H, et al. (1997) Neutral trehalase Nth1p of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein. FEBS Lett 412(3):615-20 SGD PMID 9276477
  5. submitted by Jeff Ubersax on 2004-01-21

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