YKR010C

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Systematic name YKR010C
Gene name TOF2
Aliases
Feature type ORF, Verified
Coordinates Chr XI:461239..458924
Primary SGDID S000001718


Description of YKR010C: Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site[1][2][3][4]




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References

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  1. Geil C, et al. (2008) A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis. Curr Biol 18(13):1001-5 SGD PMID 18595708
  2. Huang J, et al. (2006) Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev 20(20):2887-901 SGD PMID 17043313
  3. Johzuka K and Horiuchi T (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35 SGD PMID 19362534
  4. Waples WG, et al. (2009) Putting the Brake on FEAR: Tof2 Promotes the Biphasic Release of Cdc14 Phosphatase during Mitotic Exit. Mol Biol Cell 20(1):245-55 SGD PMID 18923139

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