YKL108W
Share your knowledge...Edit this entry! <protect>
| Systematic name | YKL108W |
| Gene name | SLD2 |
| Aliases | DRC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:234426..235787 |
| Primary SGDID | S000001591 |
Description of YKL108W: Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint[1][2][3][4][5][6][7][8]
</protect>
Community Commentary
About Community Commentary. Please share your knowledge!
Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [9]
<protect>
References
See Help:References on how to add references
- ↑ Bruck I, et al. (2011) Enabling association of the GINS tetramer with the Mcm2-7 complex by phosphorylated Sld2 protein and single-stranded origin DNA. J Biol Chem () SGD PMID 21868389
- ↑ Kanter DM and Kaplan DL (2011) Sld2 binds to origin single-stranded DNA and stimulates DNA annealing. Nucleic Acids Res 39(7):2580-92 SGD PMID 21109535
- ↑ Masumoto H, et al. (2002) S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Nature 415(6872):651-5 SGD PMID 11807498
- ↑ Muramatsu S, et al. (2010) CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol {varepsilon}, and GINS in budding yeast. Genes Dev 24(6):602-12 SGD PMID 20231317
- ↑ Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 SGD PMID 17167415
- ↑ 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 SGD PMID 10097122
- ↑ Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 SGD PMID 17167417
- ↑ submitted by Jeff Ubersax on 2004-01-27
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
