YCL054W

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Systematic name YCL054W
Gene name SPB1
Aliases
Feature type ORF, Verified
Coordinates Chr III:31449..33974
Primary SGDID S000000559


Description of YCL054W: AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants[1][2][3]




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References

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  1. Bonnerot C, et al. (2003) Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. Mol Cell 12(5):1309-15 SGD PMID 14636587
  2. Kressler D, et al. (1999) Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Nucleic Acids Res 27(23):4598-608 SGD PMID 10556316
  3. Lapeyre B and Purushothaman SK (2004) Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Mol Cell 16(4):663-9 SGD PMID 15546625

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