YJL046W

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Systematic name YJL046W
Gene name AIM22
Aliases LIP3, RRG3
Feature type ORF, Verified
Coordinates Chr X:352386..353615
Primary SGDID S000003582


Description of YJL046W: Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss[1][2][3][4][5]




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References

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  1. Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 SGD PMID 12140549
  2. Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407 SGD PMID 19300474
  3. Schonauer MS, et al. (2009) Lipoic Acid synthesis and attachment in yeast mitochondria. J Biol Chem 284(35):23234-42 SGD PMID 19570983
  4. Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4 SGD PMID 12134146
  5. Tatusov RL, et al. (1997) A genomic perspective on protein families. Science 278(5338):631-7 SGD PMID 9381173

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