YOR018W

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Systematic name YOR018W
Gene name ROD1
Aliases ART4
Feature type ORF, Verified
Coordinates Chr XV:364369..366882
Primary SGDID S000005544


Description of YOR018W: Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins[1][2][3]




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References

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  1. Andoh T, et al. (2002) PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance. FEBS Lett 525(1-3):131-4 SGD PMID 12163175
  2. Lin CH, et al. (2008) Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell 135(4):714-25 SGD PMID 18976803
  3. Wu AL, et al. (1996) ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae. J Biol Chem 271(6):2914-20 SGD PMID 8621680

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