YMR247C

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Systematic name YMR247C
Gene name RKR1
Aliases LTN1
Feature type ORF, Verified
Coordinates Chr XIII:768039..763351
Primary SGDID S000004861


Description of YMR247C: RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice[1][2][3]




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References

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  1. Bengtson MH and Joazeiro CA (2010) Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467(7314):470-3 SGD PMID 20835226
  2. Braun MA, et al. (2007) Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae. Mol Cell Biol 27(8):2800-11 SGD PMID 17283062
  3. Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 SGD PMID 16702403

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