From SGD-Wiki
(Redirected from RAD31)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YBR136W
Gene name MEC1
Aliases ESR1, RAD31, SAD3
Feature type ORF, Verified
Coordinates Chr II:505668..512774
Primary SGDID S000000340

Description of YBR136W: Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres[1][2][3][4][5][6][7][8]


Community Commentary

About Community Commentary. Please share your knowledge!



See Help:References on how to add references

  1. Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 SGD PMID 8939848
  2. Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 SGD PMID 10511543
  3. Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () SGD PMID 22289863
  4. Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 SGD PMID 8065923
  5. Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 SGD PMID 8744945
  6. Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
  7. Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 SGD PMID 9610409
  8. Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65 SGD PMID 7926756

See Help:Categories on how to add the wiki page for this gene to a Category </protect>