YJR117W

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Systematic name YJR117W
Gene name STE24
Aliases AFC1, PIO2
Feature type ORF, Verified
Coordinates Chr X:642007..643368
Primary SGDID S000003878


Description of YJR117W: Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans[1][2][3][4]




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References

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  1. Boyartchuk VL, et al. (1997) Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science 275(5307):1796-800 SGD PMID 9065405
  2. Fujimura-Kamada K, et al. (1997) A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor. J Cell Biol 136(2):271-85 SGD PMID 9015299
  3. Tam A, et al. (1998) Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing. J Cell Biol 142(3):635-49 SGD PMID 9700155
  4. Tam A, et al. (2001) The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. J Biol Chem 276(50):46798-806 SGD PMID 11581258

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