YEL031W

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Systematic name YEL031W
Gene name SPF1
Aliases COD1, PER9, PIO1
Feature type ORF, Verified
Coordinates Chr V:90258..93905
Primary SGDID S000000757


Description of YEL031W: P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1[1][2][3][4]




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Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Genotype: RHY1202
Phenotype(s): Loss of function (Null), Recessive, Viable

Deletion of COD1/SPF1 prevents the degradation of Hmg2p from being regulated. [1] [5]





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References

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  1. 1.0 1.1 Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 SGD PMID 10704442
  2. Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 SGD PMID 12058017
  3. Katrin K, et al. (2012) Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell () SGD PMID 22918956
  4. Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23 SGD PMID 10361284
  5. submitted by Stephen R. Cronin on 2003-06-13

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