YBR186W
(Redirected from PCH2)
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| Systematic name | YBR186W |
| Gene name | PCH2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:600553..602360 |
| Primary SGDID | S000000390 |
Description of YBR186W: Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation[1][2][3]
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References
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- ↑ Farmer S, et al. (2012) Budding yeast pch2, a widely conserved meiotic protein, is involved in the initiation of meiotic recombination. PLoS One 7(6):e39724 SGD PMID 22745819
- ↑ San-Segundo PA and Roeder GS (1999) Pch2 links chromatin silencing to meiotic checkpoint control. Cell 97(3):313-24 SGD PMID 10319812
- ↑ San-Segundo PA and Roeder GS (2000) Role for the silencing protein Dot1 in meiotic checkpoint control. Mol Biol Cell 11(10):3601-15 SGD PMID 11029058
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