YMR243C
(Redirected from OSR1)
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| Systematic name | YMR243C |
| Gene name | ZRC1 |
| Aliases | OSR1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:756166..754838 |
| Primary SGDID | S000004856 |
Description of YMR243C: Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain[1][2][3][4]
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References
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- ↑ Li L and Kaplan J (1998) Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. J Biol Chem 273(35):22181-7 SGD PMID 9712830
- ↑ MacDiarmid CW, et al. (2000) Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. EMBO J 19(12):2845-55 SGD PMID 10856230
- ↑ MacDiarmid CW, et al. (2003) Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock. J Biol Chem 278(17):15065-72 SGD PMID 12556516
- ↑ Tuschl K, et al. (2012) Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10, a Manganese Transporter in Man. Am J Hum Genet () SGD PMID 22341972
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