YPL052W

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Systematic name YPL052W
Gene name OAZ1
Aliases YPL052W-A
Feature type ORF, Verified
Coordinates Chr XVI:458799..459678
Primary SGDID S000005973


Description of YPL052W: Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p[1][2][3]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in sulfur limited chemostat cultures versus sulfur excess. [4] [5]





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References

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  1. Kurian L, et al. (2011) Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA.LID - 10.1038/nature10393 [doi] Nature () SGD PMID 21900894
  2. Palanimurugan R, et al. (2004) Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J 23(24):4857-67 SGD PMID 15538383
  3. Porat Z, et al. (2008) Yeast Antizyme Mediates Degradation of Yeast Ornithine Decarboxylase by Yeast but Not by Mammalian Proteasome: NEW INSIGHTS ON YEAST ANTIZYME. J Biol Chem 283(8):4528-34 SGD PMID 18089576
  4. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  5. submitted by Viktor Boer on 2003-07-25

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