YAL034W-A

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Systematic name YAL034W-A
Gene name MTW1
Aliases DSN3, NSL2
Feature type ORF, Verified
Coordinates Chr I:79718..80587
Primary SGDID S000000032


Description of YAL034W-A: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly[1]




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Alleles, Strains, and Phenotypes

Point Mutation

Allele: mtw1-1

Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Phenotype(s): Temperature(Heat) Sensitive

mtw1-1 mutants activate the spindle checkpoint in an IPL1 dependent manner. [2] [3]


Allele: mtw1-1

Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Phenotype(s): Temperature(Heat) Sensitive

mtw1-1 mutants have unattached chromosomes. [2] [3]


Interactions

Genetic

YAL034W-A is suppressed by DSN1


Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)

DSN1 is a high copy suppressor of the mtw1-1 mutant. [2] [3]


Physical

Physical interaction with CSE4
Cse4p co-immunoprecipitates with Mtw1p. [2] [3]


Physical interaction with DSN1
Mtw1p co-immunoprecipitates Dsn1p. [2] [3]





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References

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  1. De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
  2. 2.0 2.1 2.2 2.3 2.4 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
  3. 3.0 3.1 3.2 3.3 3.4 submitted by Benjamin Pinsky on 2004-03-04

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References

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