YMR116C

From SGD-Wiki
(Redirected from NAD1)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YMR116C
Gene name ASC1
Aliases CPC2, NAD1
Feature type ORF, Verified
Coordinates Chr XIII:500688..499456
Primary SGDID S000004722


Description of YMR116C: G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation[1][2][3][4][5]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!




<protect>

References

See Help:References on how to add references

  1. Chantrel Y, et al. (1998) The transcriptional regulator Hap1p (Cyp1p) is essential for anaerobic or heme-deficient growth of Saccharomyces cerevisiae: Genetic and molecular characterization of an extragenic suppressor that encodes a WD repeat protein. Genetics 148(2):559-69 SGD PMID 9504906
  2. Gerbasi VR, et al. (2004) Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression. Mol Cell Biol 24(18):8276-87 SGD PMID 15340087
  3. Hoffmann B, et al. (1999) The WD protein Cpc2p is required for repression of Gcn4 protein activity in yeast in the absence of amino-acid starvation. Mol Microbiol 31(3):807-22 SGD PMID 10048025
  4. Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
  5. Zeller CE, et al. (2007) The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast. J Biol Chem 282(34):25168-76 SGD PMID 17591772

See Help:Categories on how to add the wiki page for this gene to a Category </protect>