YOL090W
(Redirected from MSH2)
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| Systematic name | YOL090W |
| Gene name | MSH2 |
| Aliases | PMS5 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:147382..150276 |
| Primary SGDID | S000005450 |
Description of YOL090W: Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP[1][2]
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References
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- ↑ Antony E and Hingorani MM (2003) Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair. Biochemistry 42(25):7682-93 SGD PMID 12820877
- ↑ Kijas AW, et al. (2003) Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair. J Mol Biol 331(1):123-38 SGD PMID 12875840
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