YOL006C

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Systematic name YOL006C
Gene name TOP1
Aliases MAK1, MAK17
Feature type ORF, Verified
Coordinates Chr XV:315387..313078
Primary SGDID S000005366


Description of YOL006C: Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination[1][2][3]




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References

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  1. Roca J (1995) The mechanisms of DNA topoisomerases. Trends Biochem Sci 20(4):156-60 SGD PMID 7770916
  2. Thrash C, et al. (1985) Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A 82(13):4374-8 SGD PMID 2989818
  3. Woo MH, et al. (2003) Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality. Proc Natl Acad Sci U S A 100(24):13767-72 SGD PMID 14585933

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