YDR005C
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| Systematic name | YDR005C |
| Gene name | MAF1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:458103..456836 |
| Primary SGDID | S000002412 |
Description of YDR005C: Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions[1][2][3][4][5][6][7][8][9]
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Contents
Community Commentary
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DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically higher expression in phosphorus limited chemostat cultures versus phosphorus excess. [10] [11]
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References
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- ↑ Boguta M, et al. (1997) Mutation in a new gene MAF1 affects tRNA suppressor efficiency in Saccharomyces cerevisiae. Gene 185(2):291-6 SGD PMID 9055829
- ↑ Desai N, et al. (2005) Two steps in Maf1-dependent repression of transcription by RNA polymerase III. J Biol Chem 280(8):6455-62 SGD PMID 15590667
- ↑ Lee J, et al. (2009) Regulation of RNA Polymerase III Transcription Involves SCH9-dependent and SCH9-independent Branches of the Target of Rapamycin (TOR) Pathway. J Biol Chem 284(19):12604-8 SGD PMID 19299514
- ↑ Oficjalska-Pham D, et al. (2006) General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1. Mol Cell 22(5):623-32 SGD PMID 16762835
- ↑ Pluta K, et al. (2001) Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol Cell Biol 21(15):5031-40 SGD PMID 11438659
- ↑ Towpik J, et al. (2008) Derepression of RNA Polymerase III Transcription by Phosphorylation and Nuclear Export of Its Negative Regulator, Maf1. J Biol Chem 283(25):17168-74 SGD PMID 18445601
- ↑ Upadhya R, et al. (2002) Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription. Mol Cell 10(6):1489-94 SGD PMID 12504022
- ↑ Vannini A, et al. (2010) Molecular basis of RNA polymerase III transcription repression by Maf1. Cell 143(1):59-70 SGD PMID 20887893
- ↑ Wei Y, et al. (2009) Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO J 28(15):2220-30 SGD PMID 19574957
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
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