YLL019C

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Systematic name YLL019C
Gene name KNS1
Aliases L124
Feature type ORF, Verified
Coordinates Chr XII:107899..105686
Primary SGDID S000003942


Description of YLL019C: Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation[1][2][3]




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References

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  1. Lee J, et al. (2012) TOR Signaling Regulates Ribosome and tRNA Synthesis via LAMMER/Clk and GSK-3 Family Kinases. Mol Cell () SGD PMID 22364741
  2. Lee K, et al. (1996) Activity and autophosphorylation of LAMMER protein kinases. J Biol Chem 271(44):27299-303 SGD PMID 8910305
  3. Padmanabha R, et al. (1991) The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family. Mol Gen Genet 229(1):1-9 SGD PMID 1910150

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