YDL006W

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Systematic name YDL006W
Gene name PTC1
Aliases CWH47, KCS2, TPD1
Feature type ORF, Verified
Coordinates Chr IV:439909..440754
Primary SGDID S000002164


Description of YDL006W: Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation[1][2][3][4][5][6]




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References

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  1. Maeda T, et al. (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369(6477):242-5 SGD PMID 8183345
  2. Malleshaiah MK, et al. (2010) The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature 465(7294):101-5 SGD PMID 20400943
  3. Robinson MK, et al. (1994) TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation. Mol Cell Biol 14(6):3634-45 SGD PMID 8196609
  4. Roeder AD, et al. (1998) Mitochondrial inheritance is delayed in Saccharomyces cerevisiae cells lacking the serine/threonine phosphatase PTC1. Mol Biol Cell 9(4):917-30 SGD PMID 9529388
  5. Warmka J, et al. (2001) Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Mol Cell Biol 21(1):51-60 SGD PMID 11113180
  6. van Zyl WH, et al. (1989) A general screen for mutant of Saccharomyces cerevisiae deficient in tRNA biosynthesis. Genetics 123(1):55-68 SGD PMID 2680757

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