YDR173C
(Redirected from IPK2)
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| Systematic name | YDR173C |
| Gene name | ARG82 |
| Aliases | ARGR3, ARGRIII, IPK2 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:811632..810565 |
| Primary SGDID | S000002580 |
Description of YDR173C: Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes[1][2][3][4][5][6]
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References
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- ↑ Dubois E, et al. (2000) Inositol polyphosphate kinase activity of Arg82/ArgRIII is not required for the regulation of the arginine metabolism in yeast. FEBS Lett 486(3):300-4 SGD PMID 11119723
- ↑ El Alami M, et al. (2003) Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. Mol Microbiol 49(2):457-68 SGD PMID 12828642
- ↑ Odom AR, et al. (2000) A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science 287(5460):2026-9 SGD PMID 10720331
- ↑ Qui HF, et al. (1991) Dissection of the bifunctional ARGRII protein involved in the regulation of arginine anabolic and catabolic pathways. Mol Cell Biol 11(4):2169-79 SGD PMID 2005903
- ↑ Saiardi A, et al. (1999) Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol 9(22):1323-6 SGD PMID 10574768
- ↑ Zhang T, et al. (2001) The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity. FEBS Lett 494(3):208-12 SGD PMID 11311242
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