YNL102W

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Systematic name YNL102W
Gene name POL1
Aliases CDC17, CRT5, HPR3
Feature type ORF, Verified
Coordinates Chr XIV:430087..434493
Primary SGDID S000005046


Description of YNL102W: Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis[1][2][3]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]





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References

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  1. Burgers PM (1998) Eukaryotic DNA polymerases in DNA replication and DNA repair. Chromosoma 107(4):218-27 SGD PMID 9745046
  2. Foiani M, et al. (1996) A meiosis-specific protein kinase, Ime2, is required for the correct timing of DNA replication and for spore formation in yeast meiosis. Mol Gen Genet 253(3):278-88 SGD PMID 9003314
  3. Gutierrez PJ and Wang TS (2003) Genomic instability induced by mutations in Saccharomyces cerevisiae POL1. Genetics 165(1):65-81 SGD PMID 14504218
  4. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  5. submitted by Jeff Ubersax on 2004-01-29

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