YJR072C

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Systematic name YJR072C
Gene name NPA3
Aliases EPA1, GPN1
Feature type ORF, Verified
Coordinates Chr X:572124..570967
Primary SGDID S000003833


Description of YJR072C: Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II[1][2][3][4][5]




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References

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  1. Alonso B, et al. (2011) A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion. Cell Cycle 10(11) SGD PMID 21532343
  2. Dez C, et al. (2004) Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol Cell Biol 24(14):6324-37 SGD PMID 15226434
  3. Gras S, et al. (2007) Structural insights into a new homodimeric self-activated GTPase family. EMBO Rep 8(6):569-75 SGD PMID 17468740
  4. Keniry ME, et al. (2004) The identification of Pcl1-interacting proteins that genetically interact with Cla4 may indicate a link between G1 progression and mitotic exit. Genetics 166(3):1177-86 SGD PMID 15082539
  5. Staresincic L, et al. (2011) GTP-dependent binding and nuclear transport of RNA polymerase II by NPA3. J Biol Chem () SGD PMID 21844196

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