YJR072C
(Redirected from GPN1)
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| Systematic name | YJR072C |
| Gene name | NPA3 |
| Aliases | EPA1, GPN1 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:572124..570967 |
| Primary SGDID | S000003833 |
Description of YJR072C: Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II[1][2][3][4][5]
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References
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- ↑ Alonso B, et al. (2011) A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion. Cell Cycle 10(11) SGD PMID 21532343
- ↑ Dez C, et al. (2004) Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol Cell Biol 24(14):6324-37 SGD PMID 15226434
- ↑ Gras S, et al. (2007) Structural insights into a new homodimeric self-activated GTPase family. EMBO Rep 8(6):569-75 SGD PMID 17468740
- ↑ Keniry ME, et al. (2004) The identification of Pcl1-interacting proteins that genetically interact with Cla4 may indicate a link between G1 progression and mitotic exit. Genetics 166(3):1177-86 SGD PMID 15082539
- ↑ Staresincic L, et al. (2011) GTP-dependent binding and nuclear transport of RNA polymerase II by NPA3. J Biol Chem () SGD PMID 21844196
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