YNL098C

From SGD-Wiki
(Redirected from GLC5)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YNL098C
Gene name RAS2
Aliases CTN5, CYR3, GLC5, TSL7
Feature type ORF, Verified
Coordinates Chr XIV:440570..439602
Primary SGDID S000005042


Description of YNL098C: GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes[1][2][3]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

Alleles, Strains, and Phenotypes

Other Mutation

Strain Background: W303-1B (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Together with: YFH1
Phenotype(s): Viable Mutation type(s): transposon insertion

A C-terminal truncation of RAS2 increased mRNA levels of CIT2 by a factor of two. [4] [5]


Interactions

Genetic

YNL098C is a suppressor of YFH1


Strain Background: W303-1B (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Together with: YFH1
Mutation type(s): partial deletion, deletion

A mutation in RAS2 supressed a growth defect of deltaYFH1 strain on toxic levels of iron in growth media. [4] [5]





<protect>

References

See Help:References on how to add references

  1. Bhattacharya S, et al. (1995) Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proc Natl Acad Sci U S A 92(7):2984-8 SGD PMID 7708760
  2. Gimeno CJ, et al. (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68(6):1077-90 SGD PMID 1547504
  3. Kataoka T, et al. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45 SGD PMID 6327067
  4. 4.0 4.1 Kucej M and Foury F (2003) Iron toxicity protection by truncated Ras2 GTPase in yeast strain lacking frataxin. Biochem Biophys Res Commun 310(3):986-91 SGD PMID 14550302
  5. 5.0 5.1 submitted by Martin Kucej on 2004-03-26

See Help:Categories on how to add the wiki page for this gene to a Category </protect> <protect>

References

See Help:References on how to add references

See Help:Categories on how to add the wiki page for this gene to a Category </protect>