YLR060W

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Systematic name YLR060W
Gene name FRS1
Aliases
Feature type ORF, Verified
Coordinates Chr XII:260979..262766
Primary SGDID S000004050


Description of YLR060W: Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control[1][2][3]




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References

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  1. Aphasizhev R, et al. (1996) Conservation in evolution for a small monomeric phenylalanyl-tRNA synthetase of the tRNA(Phe) recognition nucleotides and initial aminoacylation site. Biochemistry 35(1):117-23 SGD PMID 8555164
  2. Roy H, et al. (2005) Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase. J Biol Chem 280(46):38186-92 SGD PMID 16162501
  3. Sanni A, et al. (1988) Structure and expression of the genes encoding the alpha and beta subunits of yeast phenylalanyl-tRNA synthetase. J Biol Chem 263(30):15407-15 SGD PMID 3049607

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