YGR195W

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Systematic name YGR195W
Gene name SKI6
Aliases ECM20, RRP41
Feature type ORF, Verified
Coordinates Chr VII:888882..889622
Primary SGDID S000003427


Description of YGR195W: Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)[1][2][3][4][5][6]




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References

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  1. Allmang C, et al. (1999) The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev 13(16):2148-58 SGD PMID 10465791
  2. Benard L, et al. (1998) Ski6p is a homolog of RNA-processing enzymes that affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis. Mol Cell Biol 18(5):2688-96 SGD PMID 9566888
  3. Dziembowski A, et al. (2007) A single subunit, Dis3, is essentially responsible for yeast exosome core activity. Nat Struct Mol Biol 14(1):15-22 SGD PMID 17173052
  4. Liu Q, et al. (2006) Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell 127(6):1223-37 SGD PMID 17174896
  5. Mitchell P, et al. (1997) The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Cell 91(4):457-66 SGD PMID 9390555
  6. Synowsky SA, et al. (2006) Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex. Mol Cell Proteomics 5(9):1581-92 SGD PMID 16829593

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