YCL050C

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Systematic name YCL050C
Gene name APA1
Aliases DTP1
Feature type ORF, Verified
Coordinates Chr III:38801..37836
Primary SGDID S000000555


Description of YCL050C: AP4A phosphorylase; bifunctional diadenosine 5',5-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving the substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; APA1 has a paralog, APA2, that arose from the whole genome duplication[1][2][3][4]




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References

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  1. Booth JW and Guidotti G (1995) An alleged yeast polyphosphate kinase is actually diadenosine-5', 5'-P1,P4-tetraphosphate alpha,beta-phosphorylase. J Biol Chem 270(33):19377-82 SGD PMID 7642617
  2. Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
  3. Lazewska D and Guranowski A (1990) P alpha-chiral phosphorothioate analogues of bis(5'-adenosyl)tetraphosphate (Ap4A); their enzymatic synthesis and degradation. Nucleic Acids Res 18(20):6083-8 SGD PMID 2172926
  4. Plateau P, et al. (1990) Catabolism of bis(5'-nucleosidyl) tetraphosphates in Saccharomyces cerevisiae. J Bacteriol 172(12):6892-9 SGD PMID 2174863

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