YGL043W
(Redirected from DST1)
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| Systematic name | YGL043W |
| Gene name | DST1 |
| Aliases | PPR2 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:417483..418412 |
| Primary SGDID | S000003011 |
Description of YGL043W: General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress[1][2][3][4][5]
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References
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- ↑ Davie JK and Kane CM (2000) Genetic interactions between TFIIS and the Swi-Snf chromatin-remodeling complex. Mol Cell Biol 20(16):5960-73 SGD PMID 10913179
- ↑ Gomez-Herreros F, et al. (2012) TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress. Nucleic Acids Res 40(14):6508-19 SGD PMID 22544605
- ↑ Olmsted VK, et al. (1998) Yeast transcript elongation factor (TFIIS), structure and function. I: NMR structural analysis of the minimal transcriptionally active region. J Biol Chem 273(35):22589-94 SGD PMID 9712887
- ↑ Ubukata T, et al. (2003) Cleavage, but not read-through, stimulation activity is responsible for three biologic functions of transcription elongation factor S-II. J Biol Chem 278(10):8580-5 SGD PMID 12496271
- ↑ Wu J, et al. (1996) In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS. Proc Natl Acad Sci U S A 93(21):11552-7 SGD PMID 8876173
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