YOR127W

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Systematic name YOR127W
Gene name RGA1
Aliases DBM1, THE1
Feature type ORF, Verified
Coordinates Chr XV:561170..564193
Primary SGDID S000005653


Description of YOR127W: GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth[1][2]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]





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References

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  1. Smith GR, et al. (2002) GTPase-activating proteins for Cdc42. Eukaryot Cell 1(3):469-80 SGD PMID 12455995
  2. Stevenson BJ, et al. (1995) Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev 9(23):2949-63 SGD PMID 7498791
  3. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  4. submitted by Jeff Ubersax on 2004-01-29

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