YLR117C
(Redirected from CLF1)
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| Systematic name | YLR117C |
| Gene name | CLF1 |
| Aliases | NTC77, SYF3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:384534..382471 |
| Primary SGDID | S000004107 |
Description of YLR117C: Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins[1][2][3][4][5][6]
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References
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- ↑ Ben-Yehuda S, et al. (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17 SGD PMID 11102353
- ↑ Chen CH, et al. (2006) Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. RNA 12(5):765-74 SGD PMID 16540691
- ↑ Chung S, et al. (1999) Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition. RNA 5(8):1042-54 SGD PMID 10445879
- ↑ Tardiff DF and Rosbash M (2006) Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly. RNA 12(6):968-79 SGD PMID 16618970
- ↑ Vincent K, et al. (2003) Genetic interactions with CLF1 identify additional pre-mRNA splicing factors and a link between activators of yeast vesicular transport and splicing. Genetics 164(3):895-907 SGD PMID 12871902
- ↑ Wang Q, et al. (2003) The Clf1p splicing factor promotes spliceosome assembly through N-terminal tetratricopeptide repeat contacts. J Biol Chem 278(10):7875-83 SGD PMID 12509417
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