YHR135C

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Systematic name YHR135C
Gene name YCK1
Aliases CKI2
Feature type ORF, Verified
Coordinates Chr VIII:374310..372694
Primary SGDID S000001177


Description of YHR135C: Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p[1][2][3][4][5][6][7][8]




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References

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  1. Feng Y and Davis NG (2000) Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane. Mol Cell Biol 20(14):5350-9 SGD PMID 10866691
  2. Hicke L, et al. (1998) Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization. J Cell Biol 141(2):349-58 SGD PMID 9548714
  3. Marchal C, et al. (2000) Casein kinase I-dependent phosphorylation within a PEST sequence and ubiquitination at nearby lysines signal endocytosis of yeast uracil permease. J Biol Chem 275(31):23608-14 SGD PMID 10811641
  4. Robinson LC, et al. (1992) Yeast casein kinase I homologues: an essential gene pair. Proc Natl Acad Sci U S A 89(1):28-32 SGD PMID 1729698
  5. Robinson LC, et al. (1993) Casein kinase I-like protein kinases encoded by YCK1 and YCK2 are required for yeast morphogenesis. Mol Cell Biol 13(5):2870-81 SGD PMID 8474447
  6. Robinson LC, et al. (1999) The Yck2 yeast casein kinase 1 isoform shows cell cycle-specific localization to sites of polarized growth and is required for proper septin organization. Mol Biol Cell 10(4):1077-92 SGD PMID 10198058
  7. Roth AF, et al. (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol 159(1):23-8 SGD PMID 12370247
  8. Wang PC, et al. (1992) Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1. Mol Biol Cell 3(3):275-86 SGD PMID 1627830

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