YDL017W

From SGD-Wiki
(Redirected from CDC7)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YDL017W
Gene name CDC7
Aliases LSD6, SAS1
Feature type ORF, Verified
Coordinates Chr IV:424209..425732
Primary SGDID S000002175


Description of YDL017W: DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p[1][2][3][4][5]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!




<protect>

References

See Help:References on how to add references

  1. Bell SP and Dutta A (2002) DNA replication in eukaryotic cells. Annu Rev Biochem 71():333-74 SGD PMID 12045100
  2. Lo HC, et al. (2011) Cdc7-Dbf4 is a gene-specific regulator of meiotic gene expression in yeast. Mol Cell Biol () SGD PMID 22106412
  3. Matos J, et al. (2008) Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I. Cell 135(4):662-78 SGD PMID 19013276
  4. Valentin G, et al. (2006) Dual role of the Cdc7-regulatory protein Dbf4 during yeast meiosis. J Biol Chem 281(5):2828-34 SGD PMID 16319063
  5. Wan L, et al. (2006) Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics 174(4):1767-74 SGD PMID 17057233

See Help:Categories on how to add the wiki page for this gene to a Category </protect>