YCR079W
(Redirected from AUP1)
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| Systematic name | YCR079W |
| Gene name | PTC6 |
| Aliases | AUP1, PPP2 |
| Feature type | ORF, Verified |
| Coordinates | Chr III:252845..254173 |
| Primary SGDID | S000002133 |
Description of YCR079W: Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase[1][2][3][4][5]
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References
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- ↑ Gey U, et al. (2008) Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem 283(15):9759-67 SGD PMID 18180296
- ↑ Ruan H, et al. (2007) The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res 7(2):209-15 SGD PMID 17002782
- ↑ Sakumoto N, et al. (2002) A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast 19(7):587-99 SGD PMID 11967829
- ↑ Tal R, et al. (2007) Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 282(8):5617-24 SGD PMID 17166847
- ↑ Tomaska L (2000) Mitochondrial protein phosphorylation: lessons from yeasts. Gene 255(1):59-64 SGD PMID 10974565
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