YNL223W

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Systematic name YNL223W
Gene name ATG4
Aliases APG4, AUT2
Feature type ORF, Verified
Coordinates Chr XIV:227370..228854
Primary SGDID S000005167


Description of YNL223W: Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation[1][2][3]




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References

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  1. Kirisako T, et al. (2000) The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol 151(2):263-76 SGD PMID 11038174
  2. Meijer WH, et al. (2007) ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 3(2):106-16 SGD PMID 17204848
  3. Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160

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