YDL100C

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Systematic name YDL100C
Gene name GET3
Aliases ARR4
Feature type ORF, Verified
Coordinates Chr IV:283176..282112
Primary SGDID S000002258


Description of YDL100C: Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity[1][2][3][4]




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References

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  1. Lee MJ and Dohlman HG (2008) Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol 18(3):211-5 SGD PMID 18261907
  2. Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19 SGD PMID 16269340
  3. Schuldiner M, et al. (2008) The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell 134(4):634-45 SGD PMID 18724936
  4. Shen J, et al. (2003) The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance. Biometals 16(3):369-78 SGD PMID 12680698

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