YBR128C
(Redirected from APG14)
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| Systematic name | YBR128C |
| Gene name | ATG14 |
| Aliases | APG14, CVT12 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:494115..493081 |
| Primary SGDID | S000000332 |
Description of YBR128C: Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor[1][2][3][4]
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References
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- ↑ Kametaka S, et al. (1998) Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 273(35):22284-91 SGD PMID 9712845
- ↑ Kihara A, et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519-30 SGD PMID 11157979
- ↑ Sun Q, et al. (2008) Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 105(49):19211-6 SGD PMID 19050071
- ↑ Suzuki K, et al. (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12(2):209-18 SGD PMID 17295840
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