YDL008W

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Systematic name YDL008W
Gene name APC11
Aliases
Feature type ORF, Verified
Coordinates Chr IV:433497..433994
Primary SGDID S000002166


Description of YDL008W: Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity[1][2]




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References

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  1. Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 SGD PMID 10465783
  2. Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 SGD PMID 9469814

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