YKR016W
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| Systematic name | YKR016W |
| Gene name | FCJ1 |
| Aliases | AIM28, FMP13 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:469717..471339 |
| Primary SGDID | S000001724 |
Description of YKR016W: Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane[1][2][3][4][5]
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References
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- Jump up ↑ Frederick RL, et al. (2008) Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics 178(2):825-37 SGD PMID 18245340
- Jump up ↑ Harner M, et al. (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J () SGD PMID 22009199
- Jump up ↑ Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol () SGD PMID 21987634
- Jump up ↑ Rabl R, et al. (2009) Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol 185(6):1047-63 SGD PMID 19528297
- Jump up ↑ von der Malsburg K, et al. (2011) Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev Cell () SGD PMID 21944719
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