YGL071W
(Redirected from AFT1)
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| Systematic name | YGL071W |
| Gene name | AFT1 |
| Aliases | RCS1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:372012..374084 |
| Primary SGDID | S000003039 |
Description of YGL071W: Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm[1][2][3][4]
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References
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- ↑ Li H, et al. (2011) Histidine 103 in Fra2 Is an Iron-Sulfur Cluster Ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required for in Vivo Iron Signaling in Yeast. J Biol Chem 286(1):867-76 SGD PMID 20978135
- ↑ Pujol-Carrion N, et al. (2006) Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae. J Cell Sci 119(Pt 21):4554-64 SGD PMID 17074835
- ↑ Shakoury-Elizeh M, et al. (2004) Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Mol Biol Cell 15(3):1233-43 SGD PMID 14668481
- ↑ Yamaguchi-Iwai Y, et al. (1996) Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J 15(13):3377-84 SGD PMID 8670839
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