YLR397C

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Systematic name YLR397C
Gene name AFG2
Aliases DRG1
Feature type ORF, Verified
Coordinates Chr XII:914892..912550
Primary SGDID S000004389


Description of YLR397C: ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs[1][2][3]




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References

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  1. Pertschy B, et al. (2007) Cytoplasmic Recycling of 60S Preribosomal Factors Depends on the AAA Protein Drg1. Mol Cell Biol 27(19):6581-92 SGD PMID 17646390
  2. Thorsness PE, et al. (1993) AFG2, an essential gene in yeast, encodes a new member of the Sec18p, Pas1p, Cdc48p, TBP-1 family of putative ATPases. Yeast 9(11):1267-71 SGD PMID 8109176
  3. Zakalskiy A, et al. (2002) Structural and enzymatic properties of the AAA protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization. J Biol Chem 277(30):26788-95 SGD PMID 12006565

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