YJR117W
(Redirected from AFC1)
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| Systematic name | YJR117W |
| Gene name | STE24 |
| Aliases | AFC1, PIO2 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:642007..643368 |
| Primary SGDID | S000003878 |
Description of YJR117W: Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans[1][2][3][4]
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References
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- ↑ Boyartchuk VL, et al. (1997) Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science 275(5307):1796-800 SGD PMID 9065405
- ↑ Fujimura-Kamada K, et al. (1997) A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor. J Cell Biol 136(2):271-85 SGD PMID 9015299
- ↑ Tam A, et al. (1998) Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing. J Cell Biol 142(3):635-49 SGD PMID 9700155
- ↑ Tam A, et al. (2001) The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. J Biol Chem 276(50):46798-806 SGD PMID 11581258
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